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General Review Article

靶向缝隙连接：重度抑郁症治疗的新见解

卷 26, 期 20, 2019

页: [3775 - 3791] 页: 17

弟呕挨: 10.2174/0929867325666180327103530

价格: $65

摘要

背景：重度抑郁症（MDD）是一种多因素慢性和使人衰弱的情绪疾病，终生患病率高，死亡率高。这种疾病的治疗方法并非对所有患者都有效，表明需要寻找新的治疗靶标。 目的：本综述旨在更新我们对星形胶质间隙连接和半通道在MDD中的参与程度的了解，并展示它们如何成为治疗这种病理学的潜在靶标。 方法：本综述中使用的方法包括相关文献的系统汇编。 结果与结论：使用抑郁症的啮齿动物模型，MDD患者海马组织的基因分析以及MDD患者大脑的验尸研究表明，星形胶质间隙连接功能障碍可能是MDD病因的一部分。大鼠，大鼠培养的皮质星形胶质细胞和人星形细胞瘤细胞系的长期抗抑郁治疗支持以下假设：星形胶质细胞之间间隙连接偶联的上调可能是抗抑郁药治疗作用的潜在机制。但是，最近的两项功能研究表明，连接蛋白43的半通道活性是几种抗抑郁药作用方式的一部分，星形胶质细胞间隙连接细胞间的通讯和半通道对抗抑郁药的反应有不同的作用。即使它们成为新的和更积极的治疗方法的新治疗靶标，也需要进一步的研究来破译星形胶质间隙连接和半通道在MDD中的复杂作用。

关键词: 抗抑郁药，星形胶质细胞，中枢神经系统，连接蛋白，抑郁症，间隙连接，半通道，pannexins。

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