A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin

Title:A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin

Volume: 13 Issue: 2

Author(s): Jhanvi J. Vaghela*, Vivek N. Nimbark, Bhavesh C. Chavda, Hita H. Mehta and Bhargav M. Purohit

Affiliation:

• Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar – 364001, Gujarat,India

Keywords: Toxic epidermal necrolysis, Ofloxacin, SCADR, Fluoroquinolones, Stevens-johnson syndrome, PCNL.

Abstract: Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), also known as Lyell's syndrome, are rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet unclear.

Case Report: A 45-year-old male patient by chance on re-exposure to Ofloxacin developed Severe Cutaneous Adverse Drug Reaction (SCADR), diagnosed with toxic epidermal necrolysis. His comorbid conditions and systemic complications of TEN lead him to death. In developing countries, where antibiotics especially fluoroquinolones are widely prescribed, a physician should be now vigilant for such kind of SCADRs because of increasing numbers of such kind of reports.

Cite this article as:

Vaghela J. Jhanvi *, Nimbark N. Vivek , Chavda C. Bhavesh , Mehta H. Hita and Purohit M. Bhargav , A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin, Current Drug Safety 2018; 13 (2) . https://dx.doi.org/10.2174/1574886313666180302124012