Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine

Title:Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine

Volume: 16 Issue: 8

Author(s): Lauren Breithaupt, Christopher Hubel and Cynthia M. Bulik*

Affiliation:

• Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm,Sweden

Keywords: Eating disorders, genetics, GWAS, heterogeneity, anorexia nervosa, polygenic risk score, heritability, pathways.

Abstract: Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention in eating disorders.

Cite this article as:

Breithaupt Lauren , Hubel Christopher and Bulik M. Cynthia*, Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine, Current Neuropharmacology 2018; 16 (8) . https://dx.doi.org/10.2174/1570159X16666180222163450