Antibacterial Coatings Based on Chitosan for Pharmaceutical and Biomedical Applications

Title:Antibacterial Coatings Based on Chitosan for Pharmaceutical and Biomedical Applications

Volume: 24 Issue: 8

Author(s): Juliana Miguel Vaz, Daniele Pezzoli, Pascale Chevallier, Clayton Souza Campelo, Gabriele Candiani and Diego Mantovani*

Affiliation:

• Laboratory for Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering and CHU de Quebec Research Centre, Laval University, Quebec City (QC),Canada

Keywords: Chitosan, antibacterial coatings, biomedical devices, biofilm, contact-killing surfaces, biocompatibility, physisorption, grafting.

Abstract: The risk of bacterial colonization of abiotic surfaces of biomedical devices poses important challenges for the pharmaceutical and biomaterials science fields. In this scenario, antibacterial coatings have been developed, using a number of different molecules and materials. Among them, chitosan is a non-cytotoxic, biocompatible biopolymer with an inherent antimicrobial activity that has been already used in a wide variety of healthcare and industrial applications. Herein, chitosan-based antibacterial coatings are critically surveyed, with a special emphasis on their production methods, pharmaceutical and biomedical applications, along with their pros and cons, and finally highlighting the key challenges to be faced and future perspectives in this field.

Cite this article as:

Vaz Miguel Juliana, Pezzoli Daniele, Chevallier Pascale , Campelo Souza Clayton , Candiani Gabriele and Mantovani Diego*, Antibacterial Coatings Based on Chitosan for Pharmaceutical and Biomedical Applications, Current Pharmaceutical Design 2018; 24 (8) . https://dx.doi.org/10.2174/1381612824666180219143900