Colchicine in Renal Diseases: Present and Future

Title:Colchicine in Renal Diseases: Present and Future

Volume: 24 Issue: 6

Author(s): Smaragdi Marinaki, Chrysanthi Skalioti and J.N. Boletis*

Affiliation:

• National and Kapodistrian University of Athens, Medical School, Nephrology Department and Renal Transplantation Unit, Laiko Hospital Athens, Athens,Greece

Keywords: Colchicine, chronic kidney disease, fibrosis, inflammation, lipophilic alkaloid, gouty arthritis.

Abstract: Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment.

Colchicine is indicated in the prevention and treatment of gouty arthritis and familial Mediterranean fever. In this review, we summarize current and potentially future pharmacologic activities of colchicine in various renal disease entities along with pharmacokinetic and pharmacodynamic properties. Additionally, we will refer to main interactions of colchicine with medications used in renal medicine, as well as dosing recommendations in patients with reduced glomerular filtration rate.

Cite this article as:

Marinaki Smaragdi , Skalioti Chrysanthi and Boletis J.N.*, Colchicine in Renal Diseases: Present and Future, Current Pharmaceutical Design 2018; 24 (6) . https://dx.doi.org/10.2174/1381612824666180123101313