摘要
MRP4转运多种内源性和外源性物质，不仅对于解毒而且对于几种信号分子的稳态也是至关重要的。在许多病理性疾病中已报道其失调，因此MRP4似乎是有吸引力的治疗靶标。然而，MRP4抑制剂的功效仍存在争议。具有选择性调节该转运蛋白活性或改变其对某些底物的亲和力的能力的特定药理学试剂的设计代表了当前医学和化学生物学的挑战。药物合理设计漫长过程的第一步是确定治疗目标，并确定其影响给定病理的机制。为了开发具有高比活性的药理学试剂，第二步是系统地研究靶标的结构并鉴定所有可能的结合位点。使用可用的同源模型和诱变测定，在本综述中，我们概括了关于MRP结构和比对的氨基酸序列的最新知识，以鉴定环核苷酸结合的候选MRP4残基。我们还列出了迄今为止研究的最相关的MRP抑制剂，特别是考虑了药物安全性和MRP4的特异性。该荟萃分析平台可以作为MRP4 cAMP特异性转运抑制剂未来发展的基础。
关键词: MRP4 / ABCC4，cAMP，药物设计，结合位点，治疗靶标，MRP抑制剂。
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