Pharmaceutical Cocrystals as an Opportunity to Modify Drug Properties: From the Idea to Application: A Review

Title:Pharmaceutical Cocrystals as an Opportunity to Modify Drug Properties: From the Idea to Application: A Review

Volume: 24 Issue: 13

Author(s): Agnieszka Sokal*Edyta Pindelska

Affiliation:

• Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Warsaw,Poland

Keywords: Cocrystals, stability, solubility, API, drug modification, compressibility.

Abstract: The properties of many drugs which have been available on the pharmaceutical market for a long time still need to be improved. Cocrystals are the solid state drug modification which can improve properties such as low solubility, stability and mechanical properties (e.g. compressibility). In this paper, examples of how to use cocrystals to modify properties of API (Active Pharmaceutical Ingredient) will be reported. Additionally, in this review, the way from an idea of the new cocrystal to drug dosage form registration will be shortly described.

Cite this article as:

Sokal Agnieszka*, Pindelska Edyta, Pharmaceutical Cocrystals as an Opportunity to Modify Drug Properties: From the Idea to Application: A Review, Current Pharmaceutical Design 2018; 24 (13) . https://dx.doi.org/10.2174/1381612824666171226130828