Synthesis of Hitherto Unknown 4,4-Bis(methylthio)but-3-en-2-one-1,1,1,3- d4 and Its Application as 1,3-Dielectrophilic Building Block for the Synthesis of Deuterated Heterocycles and Aromatics

Title:Synthesis of Hitherto Unknown 4,4-Bis(methylthio)but-3-en-2-one-1,1,1,3- d4 and Its Application as 1,3-Dielectrophilic Building Block for the Synthesis of Deuterated Heterocycles and Aromatics

Volume: 15 Issue: 5

Author(s): T.P. Charanraj, P. Ramachandra, N. Ramesh and H. Junjappa*

Affiliation:

• Chemistry Research Unit, REVA Institute of Science and Management, Bangalore-560064,India

Keywords: Acetone-d6, α-oxoketenedithioacetal, 1, 3-dielectrophilic building block, deuterated heterocycles, aromatics, aromatic compounds.

Abstract: Acetone-d6 has been transformed for the first time to 4,4-bis(methylthio)but-3-en-2-one- 1,1,1,3-d4. This tetradeutero-α-oxoketenedithioacetal is shown to be an excellent 1,3-dielectrophilic building block for the synthesis of 5- and 6-membered deuterated heterocycles and aromatics.

Cite this article as:

Charanraj T.P. , Ramachandra P. , Ramesh N. and Junjappa H. *, Synthesis of Hitherto Unknown 4,4-Bis(methylthio)but-3-en-2-one-1,1,1,3- d4 and Its Application as 1,3-Dielectrophilic Building Block for the Synthesis of Deuterated Heterocycles and Aromatics, Letters in Organic Chemistry 2018; 15 (5) . https://dx.doi.org/10.2174/1570178615666171205095718