Recent Advances in Peroxisome Proliferator-Activated Receptor Science

Title: Recent Advances in Peroxisome Proliferator-Activated Receptor Science

Volume: 10 Issue: 4

Author(s): Barry G. Shearer and William J. Hoekstra

Affiliation:

Keywords: peroxisome proliferator, ppar, nuclear receptor, ppar agonists, ppar-specific

Abstract: The peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors, a set of three receptor sub-types encoded by distinct genes, function as lipid sensors to regulate a broad range of genes in many metabolically active tissues. Synthetic PPAR agonists have exhibited therapeutic benefits in treating diabetes and cardiovascular diseases. The discovery of PPAR-specific ligands has led to significant advancement in our understanding of the structure of these receptor proteins and the molecular mechanism of their ligand-dependent activation. Herein, we present both recent progress in the functional analysis of these orphan receptors and the confirmation of the PPARs as molecular targets for the development of new medicines to treat human metabolic disease.

Cite this article as:

Shearer G. Barry and Hoekstra J. William, Recent Advances in Peroxisome Proliferator-Activated Receptor Science, Current Medicinal Chemistry 2003; 10 (4) . https://dx.doi.org/10.2174/0929867033368295