Effect of Metformin on Plasma Fibrinogen Concentrations: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Title:Effect of Metformin on Plasma Fibrinogen Concentrations: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Volume: 24 Issue: 9

Author(s): Luis E. Simental-Mendia, Matteo Pirro, Stephen L. Atkin, Maciej Banach, Dimitri P. Mikhailidis and Amirhossein Sahebkar*

Affiliation:

• Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad,Iran

Keywords: Coagulation, fibrinogen, hemostasis, metformin, meta-analysis, thrombosis.

Abstract: Objective: Fibrinogen is a key mediator of thrombosis and it has been implicated in the pathogenesis of atherosclerosis. Because metformin has shown a potential protective effect on different atherothrombotic risk factors, we assessed in this meta-analysis its effect on plasma fibrinogen concentrations.

Methods: A systematic review and meta-analysis was carried out to identify randomized placebo-controlled trials evaluating the effect of metformin administration on fibrinogen levels. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases (by June 2, 2017) and quality of studies was performed according to Cochrane criteria. Quantitative data synthesis was conducted using a random-effects model and sensitivity analysis by the leave-one-out method. Meta-regression analysis was performed to assess the modifiers of treatment response.

Results: Meta-analysis of data from 9 randomized placebo-controlled clinical trials with 2302 patients comprising 10 treatment arms did not suggest a significant change in plasma fibrinogen concentrations following metformin therapy (WMD: -0.25 g/L, 95% CI: -0.53, 0.04, p = 0.092). The effect size was robust in the leave-one-out sensitivity analysis and remained non-significant after omission of each single study from the meta-analysis.

Conclusion: No significant effect of metformin on plasma fibrinogen concentrations was demonstrated in the current meta-analysis.

Cite this article as:

Simental-Mendia E. Luis, Pirro Matteo, Atkin L. Stephen, Banach Maciej, Mikhailidis P. Dimitri and Sahebkar Amirhossein*, Effect of Metformin on Plasma Fibrinogen Concentrations: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials, Current Pharmaceutical Design 2018; 24 (9) . https://dx.doi.org/10.2174/1381612823666171103165502