Abstract
Ammonia-lyases catalyze a wide range of processes leading to α,β-unsaturated compounds by elimination of ammonia having few features in common. They utilize an extraordinary range of prosthetic groups; e.g. coenzyme B12, dipyrromethane cofactor, pyridoxal-phosphate, or the 3,5-dihydro-5-methylidene-4H-imidazol- 4-one (MIO) prosthetic groups. In this work, ammonia-lyases are reviewed with major emphasis on various aspects of biotransformations, covering topics from the fundamental biochemistry of ammonia-lyases to their structure determined by protein crystallography.
Keywords: Ammonia-Lyases, dipyrromethane cofactor, biotransformations
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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