Phospholipid-based Immobilized Artificial Membrane (IAM) Chromatography: A Powerful Tool to Model Drug Distribution Processes

Anna    W.    Sobanska; Elzbieta       Brzezinska

doi:10.2174/1381612823666171018114331

Abstract

A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented.

Keywords: IAM chromatography, blood-brain barrier, skin permeability, oral bioavailability.

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Current Pharmaceutical Design

Title:Phospholipid-based Immobilized Artificial Membrane (IAM) Chromatography: A Powerful Tool to Model Drug Distribution Processes

Volume: 23 Issue: 44

Author(s): Anna W. Sobanska*Elzbieta Brzezinska

Affiliation:

Department of Analytical Chemistry, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz,Poland

Keywords: IAM chromatography, blood-brain barrier, skin permeability, oral bioavailability.

Abstract: A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented.

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Sobanska W. Anna *, Brzezinska Elzbieta , Phospholipid-based Immobilized Artificial Membrane (IAM) Chromatography: A Powerful Tool to Model Drug Distribution Processes, Current Pharmaceutical Design 2017; 23 (44) . https://dx.doi.org/10.2174/1381612823666171018114331

DOI https://dx.doi.org/10.2174/1381612823666171018114331	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286