Ionotropic Glutamate Receptor Biology: Effect on Synaptic Connectivity and Function in Neurological Disease

Title: Ionotropic Glutamate Receptor Biology: Effect on Synaptic Connectivity and Function in Neurological Disease

Volume: 10 Issue: 20

Author(s): G. N. Barnes and J. T. Slevin

Affiliation:

Keywords: glutamate, epilepsy, sprouting, kainic acid, kindling

Abstract: Glutamate receptor signaling is essential to normal synaptic function in the central nervous system. The major ionotropic glutamate receptors (AMPA, Kainic, and NMDA) have different synaptic functions depending upon cellular and subcellular localization, subunit composition, and second messenger systems linked to the receptors. In this review, we examine major advances in glutamate receptor biology whose physiology plays a central role in neurologic disease such as epilepsy and stroke. A key feature of glutamate receptor activation in neurologic disease is the downstream effects on cell survival, genetic expression of axon guidance cues, synaptic connectivity / formation of networks, and neuronal excitability. Identification of therapeutic pharmacologic targets and development of antagonists specific to the disease process remain central themes in epilepsy and stroke research.

Cite this article as:

Barnes N. G. and Slevin T. J., Ionotropic Glutamate Receptor Biology: Effect on Synaptic Connectivity and Function in Neurological Disease, Current Medicinal Chemistry 2003; 10 (20) . https://dx.doi.org/10.2174/0929867033456800