Abstract
There are diverse classes of compounds in the arsenal of synthetic organic chemists, which are of immense use in the synthesis of natural products. The class of α-diazocarbonyls is one of them. The compounds of this class are often used for the generation of reactive intermediates such as carbenoids and ketenes. The reactions of these intermediates have been used in the synthesis of a wide variety of organic compounds including several natural products. This article describes briefly the preparation of α-diazocarbonyls, their reactions through carbenoid and ketenes, and application of these reactions in the synthesis of several complex and biologically important natural products.
Keywords: carbenoids, ketenes, a-diazocarbonyls, natural products synthesis, reactive intermediates
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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