Proteins Commonly Linked to Autism Spectrum Disorder and Alzheimer's Disease

Title:Proteins Commonly Linked to Autism Spectrum Disorder and Alzheimer's Disease

Volume: 19 Issue: 9

Author(s): Athanasios Alexiou*, Georgia Soursou, Nagendra Sastry Yarla and Ghulam Md Ashraf*

Affiliation:

• Novel Global Community Educational Foundation, Hebersham,Australia

• King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589,Saudi Arabia

Keywords: Autism spectrum disorder, Alzheimer’s disease, proteins, developmental origins of health and diseases, neurological symptoms.

Abstract: Several years after the first publication of Barker's Hypothesis the identification of common patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the increasing number of diagnosed cases globally, scientists focused on commonly expressed and related proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer’s Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules that play a fundamental role in their development. These proteins are described and analyzed concerning the underlying pathology of these diseases.

Cite this article as:

Alexiou Athanasios *, Soursou Georgia , Yarla Sastry Nagendra and Ashraf Md Ghulam*, Proteins Commonly Linked to Autism Spectrum Disorder and Alzheimer's Disease, Current Protein & Peptide Science 2018; 19 (9) . https://dx.doi.org/10.2174/1389203718666170911145321