Design and Development of Integrase Inhibitors as Anti-HIV Agents

S.   P.   Gupta; A.   N.   Nagappa

doi:10.2174/0929867033456972

Abstract

A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds, hydrazides and amides, tetracyclines, and depsides and depsidones. For all these compounds, the important structural features essential for the inhibition of the integrase are pointed out.

Keywords: integrase inhibitors, hiv-1 integrase, oligonucleotides, double-stranded

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Current Medicinal Chemistry

Title: Design and Development of Integrase Inhibitors as Anti-HIV Agents

Volume: 10 Issue: 18

Author(s): S. P. Gupta and A. N. Nagappa

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Keywords: integrase inhibitors, hiv-1 integrase, oligonucleotides, double-stranded

Abstract: A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds, hydrazides and amides, tetracyclines, and depsides and depsidones. For all these compounds, the important structural features essential for the inhibition of the integrase are pointed out.

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Gupta P. S. and Nagappa N. A., Design and Development of Integrase Inhibitors as Anti-HIV Agents, Current Medicinal Chemistry 2003; 10 (18) . https://dx.doi.org/10.2174/0929867033456972