Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants

Title:Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants

Volume: 25 Issue: 40

Author(s): Jack Ho Wong*, Stephen Cho Wing Sze*, Tzi Bun Ng*, Randy Chi Fai Cheung, Chit Tam*, Kalin Yanbo Zhang*, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye*, Hexiang Wang, Fang Liu, David Wai Chan*, Hextan Yuen Sheung Ngan*, Ou Sha*, Guohui Li, Ryan Tse, Tak Fu Tse*Helen Chan*

Affiliation:

• School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong,China

• School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong,China

• School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong,China

• School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong,China

• School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong,China

• Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, and Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002,China

• Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong,China

• Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong,China

• Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen,China

• Vita Green Pharmaceuticals (HK) Ltd, Vita Green Health Products (HK) Ltd Genning Partners Company Limited, and Hong Kong Institute of Medical Research, Hong Kong,China

• Vita Green Pharmaceuticals (HK) Ltd, Vita Green Health Products (HK) Ltd Genning Partners Company Limited, and Hong Kong Institute of Medical Research, Hong Kong,China

Keywords: Medicinal fungi, medicinal plants, anticancer, apoptosis, mitochondria.

Abstract: The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs.

Cite this article as:

Wong Ho Jack *, Sze Cho Wing Stephen *, Ng Bun Tzi*, Cheung Chi Fai Randy , Tam Chit *, Zhang Yanbo Kalin *, Dan Xiuli , Chan Sang Yau , Shing Cho Chi William , Ng Cheuk Wing Charlene , Waye Miu Yee Mary , Liang Weicheng , Zhang Jinfang , Yang Jie , Ye Xiuyun , Lin Juan , Ye Xiujuan *, Wang Hexiang , Liu Fang , Chan Wai David*, Ngan Yuen Sheung Hextan *, Sha Ou *, Li Guohui , Tse Ryan , Tse Fu Tak *, Chan Helen *, Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants, Current Medicinal Chemistry 2018; 25 (40) . https://dx.doi.org/10.2174/0929867324666170720165005