Abstract
Background: A ligand free, microwave assisted, copper catalyzed synthetic procedure for substituted tertiary amines has been developed by using nitroarenes and secondary amines.
Methods: In the synthetic method, the targeted substituted tertiary amines were synthesized with the help of the microwave by reacting nitroarenes and substituted secondary amines in the presence of copper, potassium carbonate and methanol. Results: All substituted tertiary amines were obtained in good yields (88-94%) with the help of a microwave technique (07-12 min) in less time. The protocol adopted was ligand free. Conclusion: Microwave assisted technique will be a useful alternative protocol for the preparation of a diverse range of substituted tertiary amines.Keywords: Catalyst, copper, ligand free, microwave, nitroarenes, tertiary amines.
Graphical Abstract
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