Gene Delivery with Organic Electronic Biomaterials

Title:Gene Delivery with Organic Electronic Biomaterials

Volume: 23 Issue: 24

Author(s): Kathryn F.A. Clancy and John G. Hardy*

Affiliation:

• Department of Chemistry and Materials Science Institute, Faraday Building, Faculty of Science and Technology, Lancaster University, Lancaster, Lancashire, LA1 4YB,United Kingdom

Keywords: Organic electronics, carbon nanotubes, fullerene, graphene, conjugated polymer, gene delivery, gene therapy, biodegradable.

Abstract: Gene therapy may be capable of treating a variety of diseases, a prerequisite of which is the successful delivery of polynucleic acids (e.g., DNA, RNA) to a patient’s cells. Delivery can be achieved technologically (e.g., using electroporation), using viruses (natural gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). This article aims to give the reader an overview of the use of organic electronic materials (i.e., fullerenes, graphenes and conjugated polymers) as non-viral gene delivery vectors.

Cite this article as:

Clancy F.A. Kathryn and Hardy G. John *, Gene Delivery with Organic Electronic Biomaterials, Current Pharmaceutical Design 2017; 23 (24) . https://dx.doi.org/10.2174/1381612823666170710124137