Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets

Maria    Elizbeth    Alvarez-Sanchez; Jose    Luis    Villalpando; Laura    Itzel    Quintas-Granados; Rossana       Arroyo

doi:10.2174/1381612823666170703162754

Abstract

Polyamines are essential for many biological processes in all organisms. Here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. This review focused on the synthesis, interconversion and function of these molecules in Trichomonas vaginalis, a common sexually transmitted parasite of humans.

Keywords: Hypusination machinery, ornithine decarboxylase (ODC), polyamines, polyamine oxidase (PAO), putrescine, spermine, spermidine, Trichomonas vaginalis.

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Current Pharmaceutical Design

Title:Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets

Volume: 23 Issue: 23

Author(s): Maria Elizbeth Alvarez-Sanchez, Jose Luis Villalpando, Laura Itzel Quintas-Granados and Rossana Arroyo*

Affiliation:

R.A. Av. IPN # 2508, Col. San Pedro Zacatenco, Delg. Gustavo A. Madero, CP 07360, Mexico, D.F,Mexico

Keywords: Hypusination machinery, ornithine decarboxylase (ODC), polyamines, polyamine oxidase (PAO), putrescine, spermine, spermidine, Trichomonas vaginalis.

Abstract: Polyamines are essential for many biological processes in all organisms. Here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. This review focused on the synthesis, interconversion and function of these molecules in Trichomonas vaginalis, a common sexually transmitted parasite of humans.

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Alvarez-Sanchez Elizbeth Maria , Villalpando Luis Jose , Quintas-Granados Itzel Laura and Arroyo Rossana *, Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets, Current Pharmaceutical Design 2017; 23 (23) . https://dx.doi.org/10.2174/1381612823666170703162754

DOI https://dx.doi.org/10.2174/1381612823666170703162754	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286