Role of DNA and RNA N6-Adenine Methylation in Regulating Stem Cell Fate

Title:Role of DNA and RNA N6-Adenine Methylation in Regulating Stem Cell Fate

Volume: 13 Issue: 1

Author(s): Yunshu Wu, Chenchen Zhou and Quan Yuan*

Affiliation:

• State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu,China

Keywords: N6-adenine methylation (m6A), stem cell, epigenetic modification, cell differentiation, pluripotency, eukaryotes.

Abstract: Background: Epigenetic modifications have been evidenced to participate in eukaryotic stem cell fate decision. Among the most studied, 5-methylcytosine (m5C) and its derivatives are wellestablished epigenetic codes that play important roles in stem cell pluripotency and differentiation. Based on improved detection techniques, recent studies have succeeded in defining N6-adenine methylation (m6A) in eukaryotic DNA and RNA. The abundant m6A methylation in RNA was shown to be involved in multiple cellular metabolisms while the presence and functional potential of DNA m6A methylation in different species advanced our knowledge in the m6A-mediated biological processes.

Conclusion: m6A modification has been observed during embryogenesis and has been proposed to fine-tune stem cell regulation. The m6A methyltransferases and demethylases work together to control the dynamic state of m6A marks in genomic DNA and RNA to ensure proper cell fate transition and determination, which are vital to the development and survival of eukaryotes.

Cite this article as:

Wu Yunshu , Zhou Chenchen and Yuan Quan *, Role of DNA and RNA N6-Adenine Methylation in Regulating Stem Cell Fate, Current Stem Cell Research & Therapy 2018; 13 (1) . https://dx.doi.org/10.2174/1574888X12666170621125457