线粒体功能障碍在阿尔茨海默病进展中的作用

Title:The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease

Volume: 25 Issue: 40

关键词: 线粒体，DNA修复，dNTP池，核苷酸代谢，大脑

摘要: The current molecular understanding of Alzheimer’s disease (AD) has still not resulted in successful interventions. Mitochondrial dysfunction of the AD brain is currently emerging as a hallmark of this disease. One mitochondrial function often affected in AD is oxidative phosphorylation responsible for ATP production, but also for production of reactive oxygen species (ROS) and for the de novo synthesis of pyrimidines. This paper reviews the role of mitochondrial produced ROS and pyrimidines in the aetiology of AD and their proposed role in oxidative degeneration of macromolecules, synthesis of essential phospholipids and maintenance of mitochondrial viability in the AD brain.

Cite this article as:

The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease, Current Medicinal Chemistry 2018; 25 (40) . https://dx.doi.org/10.2174/0929867324666170616110111