Abstract
Epoxy alcohols are extremely versatile building blocks in organic synthesis, due to their general availability in both enantiomeric series. The preferred methods for the subsequent stereoselective attack of various nucleophiles (hydride, carbon nucleophiles, nitrogen nucleophiles, oxygen nucleophiles, halogen ions, etc.) in a regioselective fashion at C2 and C3 are reviewed. The application of some of these methods in the synthesis of natural products and optically active compounds are described. Finally some reactions typical of homoallylic alcohols and their corresponding hydroxyepoxides are also reported.
Keywords: Epoxy Alcohols, enantiomeric series, hydride, hydroxyepoxides, homoallylic, nitrogen nucleophiles
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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