Abstract
With the aim of offering patients a more effective drug therapy and with few side effects, it was believed in the perfect and unique interaction of the bioactive compound and the receptor or target macromolecule. This concept has changed, and multifunctional compounds show greater efficiency, particularly in the therapy of complex diseases, with a sum of origin. Among these ills, we quote: neurodegenerative diseases, cancer, parasitic and inflammatory. To fight these diseases, studies with multitarget flavonoids have been reported. Flavonoid compounds are natural products traditionally used as chemotherapy because of their numerous therapeutic activities. Here, we gather studies with multitarget in drug discovery flavonoids.
Keywords: Flavonoids, multi-target, drug, neurodegenerative, cancer, parasite, inflammation.
Graphical Abstract
Mini-Reviews in Organic Chemistry
Title:Flavonoids as Multi-Target Compounds in Drug Discovery
Volume: 14 Issue: 4
Author(s): L. Scotti*, H. Ishiki, F.J.B. Mendonça Júnior, R.M.D. Cruz, J.F. Tavares, M.F.F.M. Diniz, J.M. Barbosa Filho and M.T. Scotti
Affiliation:
- Health Sciences Center, Federal University of Paraíba, Campus I, 58051-970, João Pessoa-PB,Brazil
Keywords: Flavonoids, multi-target, drug, neurodegenerative, cancer, parasite, inflammation.
Abstract: With the aim of offering patients a more effective drug therapy and with few side effects, it was believed in the perfect and unique interaction of the bioactive compound and the receptor or target macromolecule. This concept has changed, and multifunctional compounds show greater efficiency, particularly in the therapy of complex diseases, with a sum of origin. Among these ills, we quote: neurodegenerative diseases, cancer, parasitic and inflammatory. To fight these diseases, studies with multitarget flavonoids have been reported. Flavonoid compounds are natural products traditionally used as chemotherapy because of their numerous therapeutic activities. Here, we gather studies with multitarget in drug discovery flavonoids.
Export Options
About this article
Cite this article as:
Scotti L. *, Ishiki H. , Júnior Mendonça F.J.B. , Cruz R.M.D. , Tavares J.F. , Diniz M.F.F.M. , Filho Barbosa J.M. and Scotti M.T. , Flavonoids as Multi-Target Compounds in Drug Discovery, Mini-Reviews in Organic Chemistry 2017; 14 (4) . https://dx.doi.org/10.2174/1570193X14666170518112248
DOI https://dx.doi.org/10.2174/1570193X14666170518112248 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lipid-lowering Therapy in the Diabetic Foot: Seeing the Whole Iceberg and not Just the Tip
Current Vascular Pharmacology Reporting and Interpretation of the CYP2C19 Genotyping Test for Clopidogrel Dosing
Current Pharmacogenomics and Personalized Medicine Improvement of Bioactive Potential of Canavalia Beans of Coastal Sand Dunes by Solid-Substrate Fermentation Using Rhizopus oligosporus
Current Nutrition & Food Science Expression and Role of the Calcium-Sensing Receptor in the Blood Vessel Wall
Current Pharmaceutical Biotechnology Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment
Mini-Reviews in Medicinal Chemistry Alzheimers Disease Burdens African-Americans: A Review of Epidemiological Risk Factors and Implications for Prevention and Treatment
Current Psychiatry Reviews Biomarkers in Aortic Valve Stenosis and their Clinical Significance in Transcatheter Aortic Valve Implantation
Current Medicinal Chemistry Endothelial Progenitor Cells and In-stent Restenosis
Current Stem Cell Research & Therapy Should Percutaneous Coronary Intervention be the Standard Treatment Strategy for Significant Coronary Artery Disease in all Octogenarians?
Current Cardiology Reviews Editorial from Guest Editor [Hot Topic Perinatal Stem Cells Revisited: Directions and Indications at the Crossroads Between Tissue Regeneration and Repair]
Current Stem Cell Research & Therapy Vitamin E - Occurrence, Biosynthesis by Plants and Functions in Human Nutrition
Mini-Reviews in Medicinal Chemistry Mineralocorticoid Receptor Blockade in the Protection of Target Organ Damage
Cardiovascular & Hematological Agents in Medicinal Chemistry Impact on DNA Methylation in Cancer Prevention and Therapy by Bioactive Dietary Components
Current Medicinal Chemistry Impacts of Nanoparticles on Cardiovascular Diseases: Modulating Metabolism and Function of Endothelial Cells
Current Drug Metabolism Editorial (Thematic Issue: Novel Data on the Pathogenesis of Atherosclerosis, Treatment Targets, and New Therapeutic Interventions in Lipid-Related Cardiovascular Risk Factors)
Current Pharmaceutical Design Exploration of Different Methodologies for Synthesizing Biologically Important Benzothiazoles: An Overview
Current Organic Synthesis Vascular Protective Effects of Diabetes Medications that Mimic or Increase Glucagon-Like Peptide-1 Activity
Recent Patents on Cardiovascular Drug Discovery Biological Activities of Quinoline Derivatives
Mini-Reviews in Medicinal Chemistry Multitarget Drugs of Plants Origin Acting on Alzheimer's Disease
Current Medicinal Chemistry Recent Valves used for Transluminal Implantation in Patients with Aortic Valve Stenosis
Recent Patents on Cardiovascular Drug Discovery