摘要
背景:小规模机器人技术因其靶向和获取细胞大小的位点的前景而受到越来越多的关注,这是高精度生物医学应用和药物/基因传递所必需的。利用这些智能载体,可以控制基因治疗的丢失,诱导系统性副作用,降低治疗效率。 方法:新提出的解决方案的控制,面临的主要挑战,供电、基因释放和最终载体萃取/降解转移这些智能微型机器人被用于实际应用的角度将寡核苷酸(质粒DNA,mRNA的siRNA,在不久的将来,等)。 结论:在本文中,特别是解决重要的工作要求和步骤,不同的场景和他们的努力,载体附着和释放,细胞内化,操控的担忧以及驱动系统discussed.this综述了一些有前途的实验结果与目前的非特异性基因传递方法的比较显示了机器人系统控制的基因释放。
关键词: 基因传递,微/纳米机器人,MRI驱动、趋化性、混合系统、基因释放。
Current Gene Therapy
Title:Smart Micro/Nano-robotic Systems for Gene Delivery
Volume: 17 Issue: 2
关键词: 基因传递,微/纳米机器人,MRI驱动、趋化性、混合系统、基因释放。
摘要: Background: Small scale robotics have attracted growing attention for the prospect of targeting and accessing cell-sized sites, necessary for high precision biomedical applications and drug/gene delivery. The loss of controlled gene therapy, inducing systemic side effects and reduced therapeutic efficiency, can be settled utilizing these intelligent carriers.
Methods: Newly proposed solutions for the main challenges of control, power supplying, gene release and final carrier extraction/degradation have shifted these smart miniature robots to the point of being employed for practical applications of transferring oligonucleotides (pDNA, siRNA, mRNA, etc.) in near future. Conclusion: In this paper, different scenarios and their endeavors to address the vital working demands and steps, in particular, carrier attachment and release, cell internalization, manipulation concerns as well as actuation systems are discussed.This review highlights some promising experimental results showing controlled gene release of robotic systems in comparison with current non-specific gene delivery methods.Export Options
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Cite this article as:
Smart Micro/Nano-robotic Systems for Gene Delivery, Current Gene Therapy 2017; 17 (2) . https://dx.doi.org/10.2174/1566523217666170511111000
DOI https://dx.doi.org/10.2174/1566523217666170511111000 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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