Lipid Nanoparticles as Potential Gene Therapeutic Delivery Systems for Oral Administration

Title:Lipid Nanoparticles as Potential Gene Therapeutic Delivery Systems for Oral Administration

Volume: 17 Issue: 2

Author(s): Golnar Dorraj, Juan Jose Carreras, Hugo Nunez, Issam Abushammala and Ana Melero*

Affiliation:

• Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Avenida Vicente Andres Estelles SN, 46100 Burjassot, Valencia,Spain

Keywords: Gene therapy, Lipid nanoparticles, Gene delivery, Oral route, Oral administration, Controlled release.

Abstract: Background: Gene therapy has experimented an increasing attention in the last decades, due to its enormous potential applications in the medical field. It can be defined as the use of genes or genetic material (DNA, RNA, oligonucleotides) to treat or prevent a disease state, generally a geneticbased one.

Application: Other applications, like treating viral, bacterial or parasite infections or development of vaccines are gaining also interest. Efficient gene therapy is mainly dependent on the ability of the highly labile genetic material to reach the therapeutic target. For this purpose, different delivery systems have been designed and extensively investigated. Nanoparticles offer a broad range of possibilities in design, being prepared using biocompatible and biodegradable excipients, being therefore generally considered as safe.

Conclusion: Oral delivery of the genetic material is also a great challenge, due to the complexity of this specific biological barrier. Special attention to all the intrinsic hazards for gene delivery due to the barrier must be taken into account during the particle design process. Particle design will also allow targeting to specific sites of the gastrointestinal tract. Solid lipid nanoparticles have been extensively studied in the oral drug delivery field, and also in gene delivery through other administration routes, but still not explored in oral gene delivery. In this manuscript, design considerations and particle-cell interaction mechanisms will be extensively reviewed, focusing on the oral route to encourage the scientific community to explore these valuable carriers for oral gene delivery.

Cite this article as:

Dorraj Golnar , Carreras Jose Juan, Nunez Hugo, Abushammala Issam and Melero Ana*, Lipid Nanoparticles as Potential Gene Therapeutic Delivery Systems for Oral Administration, Current Gene Therapy 2017; 17 (2) . https://dx.doi.org/10.2174/1566523217666170510163038

DOI https://dx.doi.org/10.2174/1566523217666170510163038	Print ISSN 1566-5232
Publisher Name Bentham Science Publisher	Online ISSN 1875-5631