5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy

Title:5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy

Volume: 16 Issue: 1

Author(s): Hongyan Zhao, Yang Lin*, Shurui Chen, Xin Li*Hongliang Huo*

Affiliation:

• Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041,China

• Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041,China

• School of Life Science Northeast Normal University, Changchun, Jilin 130024,China

Keywords: 5-HT3 receptor, epilepsy, antagonists, Neuron, GABA, NMDA.

Abstract: Background: Epilepsy is a syndrome of brain dysfunction caused by spontaneous, abnormal discharge. Many anti-epileptic drugs have developed in past decades. 5-HT is an important neurotransmitter in the central and peripheral nervous system of the human body which is involved in a number of physiological activities, such as sensation, movement, and behavior. 5-HT subtype have been divided into seven sub-groups from 5-HT1 to 5HT7. However, the role of 5-HT3 receptor on epilepsy is unclear. Therefore, in this article, the possible role of 5-HT3 receptor on epilepsy was systemically reviewed.

Methods: Data were collected from Web of Science, Medline, Pubmed, Scopus, through searching of these keywords: “5-HT3” and “epilepsy”.

Results: An increasing number of studies have shown that the activation of the 5-HT3 receptor can inhibit epileptic seizures, while inhibition of the 5-HT3 receptor can promote spike waves.

Conclusion: In this review, we discuss the relationship between the 5HT3 receptor and epilepsy; this review may provide a new insight for clinical application of epilepsy treatment.

Cite this article as:

Zhao Hongyan , Lin Yang *, Chen Shurui , Li Xin*, Huo Hongliang*, 5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy, Current Neuropharmacology 2018; 16 (1) . https://dx.doi.org/10.2174/1570159X15666170508170412