摘要
背景:脑内出血患者早期血肿生长并不罕见。 独立地预测不良结果是一种破坏性的并发症。 早期血肿扩大通常定义为重复CT扫描时血肿体积绝对增加大于33%。 迄今为止,没有理想的动物模型可以模拟早期血肿生长的确切病理生理过程。 目的:本次脑出血早期血肿扩大的综述讨论了旨在改善结局的定义,病理生理学,危险因素和新型治疗方案。 结论:新型影像学预测因素如CT血管造影斑点和CT混合征可能预示脑出血患者早期血肿生长。 监测和调节血压可以改善结果。 脑内出血患者的血压迅速降低至<140 mm Hg可能是安全的。
关键词: 原发性脑出血,血肿扩大,机制,预测因素。
图形摘要
Current Drug Targets
Title:Early Hematoma Enlargement in Primary Intracerebral Hemorrhage
Volume: 18 Issue: 12
关键词: 原发性脑出血,血肿扩大,机制,预测因素。
摘要: Background: Early hematoma growth is not uncommon in patients with intracerebral hemorrhage. It is a devastating complication that independently predicts poor outcome. The early hematoma enlargement is usually defined as an absolute increase in hematoma volume of greater than 33% on repeat CT scan. To date, no ideal animal model can mimic the exact pathophysiological process of early hematoma growth.
Objective: This review of early hematoma enlargement in primary intracerebral hemorrhage discusses definitions, pathophysiology, risk factors, and novel treatment options aimed at improving outcomes. Conclusion: Novel imaging predictors such as CT angiography spot sign and CT blend sign may predict early hematoma growth in patients with intracerebral hemorrhage. Monitoring and modulation of blood pressure may improve outcomes. Rapid reduction of blood pressure to <140 mm Hg may be safe in patients with intracerebral hemorrhage.Export Options
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Cite this article as:
Early Hematoma Enlargement in Primary Intracerebral Hemorrhage, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450118666170427151011
DOI https://dx.doi.org/10.2174/1389450118666170427151011 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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