Abstract
Background: Vitamin D deficiency is one determinant of secondary hyperparathyroidism in the course of Chronic Kidney Disease (CKD). However, numerous studies support the notion that vitamin D may exert pleiotropic effects aside of mineral metabolism control. Indeed, vitamin D receptor has been identified in a great variety of tissues and its activation contributes to the parathyroid, intestine, cardiovascular and immune system regulation.
Conclusion: We herein review vitamin D metabolism and effects with a specific emphasis on the potential impact of vitamin D receptor modulation aside from parathyroid hormone control.Keywords: CKD-MBD, vitamin D, paracalcitol, Vitamin D receptor, vitamin D deficiency.
Graphical Abstract
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