Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update

Title:Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update

Volume: 25 Issue: 1

Author(s): Ylenia Cau, Daniela Valensin, Mattia Mori, Sara Draghi and Maurizio Botta*

Affiliation:

• Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, Siena,Italy

Keywords: 14-3-3, cancer, neurodegeneration, protein-protein interaction, small molecules, drug discovery, phosphorylation.

Abstract: 14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-protein interactions (PPIs). They are usually found in all eukaryotes with a conserved secondary structure and high sequence homology among species. 14-3-3 proteins are involved in many physiological and pathological cellular processes either by triggering or interfering with the activity of specific protein partners. In the last years, the scientific community has collected many evidences on the role played by seven human 14-3-3 isoforms in cancer or neurodegenerative diseases. Indeed, these proteins regulate the molecular mechanisms associated to these diseases by interacting with (i) oncogenic and (ii) pro-apoptotic proteins and (iii) with proteins involved in Parkinson and Alzheimer diseases. The discovery of small molecule modulators of 14-3-3 PPIs could facilitate complete understanding of the physiological role of these proteins, and might offer valuable therapeutic approaches for these critical pathological states.

Cite this article as:

Cau Ylenia , Valensin Daniela , Mori Mattia, Draghi Sara and Botta Maurizio *, Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update, Current Medicinal Chemistry 2018; 25 (1) . https://dx.doi.org/10.2174/0929867324666170426095015