摘要
背景:非酒精性脂肪肝(NAFLD)是最常见的慢性肝病,是引起隐匿性肝硬化的主要原因,并一直与相关的代谢性dis有关。顺序,如血脂异常和2型糖尿病(T2D)。然而,NAFLD的发病机制尚不清楚,目前还没有建立治疗NAFLD的治疗方案。腺苷单酚SPHOT(AMP)激活的蛋白激酶(AMPK)是细胞的主要能量传感器,被认为是肝脏脂质代谢和糖代谢的关键调节因子。最近,新的证据表明许多植物来源的天然产物能够通过靶向AMPK来改善NAFLD。 方法:对PubMed在2016年6月发表的相关文献进行检索。 结果:在了解植物源性天然产物对NAFLD的保护作用方面取得了重大进展。多种天然产物,包括生物碱(B)黄连素、去乙基小檗碱、尼古丁、咖啡因等,多酚(白藜芦醇、葛根素、姜黄素、咖啡酸等)和其他化合物(β-石竹烯、天麻素、化合物K、白桦碱)在临床前的研究中显示出了有希望的结果。这些化合物的机理研究集中在它们激活AMPK及其下游效应物参与脂质代谢。abolish废除,废止 结论:本研究结果证实植物源性天然产物能激活AMPK信号通路是治疗非酒精性脂肪肝的潜在药物。VVV
关键词: 非酒精性脂肪肝病,AMP激酶,天然产物,脂质代谢,生物碱,多酚,抗氧化,抗炎。
Current Medicinal Chemistry
Title:Hepatic AMP Kinase as a Potential Target for Treating Nonalcoholic Fatty Liver Disease: Evidence from Studies of Natural Products
Volume: 25 Issue: 8
关键词: 非酒精性脂肪肝病,AMP激酶,天然产物,脂质代谢,生物碱,多酚,抗氧化,抗炎。
摘要: Background: Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is the leading cause of cryptogenic cirrhosis and has consistently been implicated in related metabolic disorders, such as dyslipidemia and type 2 diabetes (T2D). However, the pathogenesis of NAFLD remains to be elucidated, and no established therapeutic regimens for treating NAFLD exist. Adenosine monophosphate (AMP)-activated protein kinase (AMPK), the main cellular energy sensor, has been implicated as a key regulator of hepatic lipid and glucose metabolism. Recently, emerging evidence indicates that many plant-derived natural products are capable of ameliorating NAFLD by targeting AMPK.
Methods: The published literature in PubMed relating to this topic was searched through June 2016.
Results: Significant advances have been made with respect to understanding the protective effects of plant-derived natural products against NAFLD. A variety of natural products, including alkaloids (berberine, demethyleneberberine, nicotine, caffeine, etc.), polyphenols (resveratrol, puerarin, curcumin, caffeic acid, etc.) and other compounds (β- caryophyllene, gastrodin, compound K, betulinic acid, etc.), have demonstrated promising results in preclinical studies. Mechanistic studies of these compounds have focused on their activation of AMPK and its downstream effectors involved in lipid metabolism.
Conclusion: The findings of this review confirm that plant-derived natural products capable of activating the AMPK signaling pathway are potential therapeutic agents for NAFLD.
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Cite this article as:
Hepatic AMP Kinase as a Potential Target for Treating Nonalcoholic Fatty Liver Disease: Evidence from Studies of Natural Products, Current Medicinal Chemistry 2018; 25 (8) . https://dx.doi.org/10.2174/0929867324666170404142450
DOI https://dx.doi.org/10.2174/0929867324666170404142450 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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