Medicinal Plants as Protective Strategies Against Parkinson's Disease

Title:Medicinal Plants as Protective Strategies Against Parkinson's Disease

Volume: 23 Issue: 28

Author(s): Natalia Areiza Mazo, Valentina Echeverria*, Ricardo Cabezas, Marco Avila-Rodriguez, Vadim V. Tarasov, Nagendra S. Yarla, Gjumrakch Aliev and George E. Barreto

Affiliation:

• Universidad San Sebastian, Lientur 1457, Concepcion, 4030000,Chile

Keywords: Parkinson's Disease, phytochemicals, neuroprotective fruits, signaling pathways, transcription factors, dopaminergic neurons.

Abstract: Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-κB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds.

Cite this article as:

Mazo Areiza Natalia , Echeverria Valentina*, Cabezas Ricardo , Avila-Rodriguez Marco , Tarasov V. Vadim , Yarla S. Nagendra , Aliev Gjumrakch and Barreto E. George, Medicinal Plants as Protective Strategies Against Parkinson's Disease, Current Pharmaceutical Design 2017; 23 (28) . https://dx.doi.org/10.2174/1381612823666170316142803