摘要
在过去的二十年中,烯烃复分解已经成为设计合成天然产物和活性药物成分的新途径的新途径。在许多情况下,基于烯烃复分解策略的合成在提高总收率,改善合成范围和减少步骤方面提供了重要途径。另一方面,近十年来,微波辅助化学取得了令人难以置信的发展,迅速开辟了有机合成和均相催化的新领域。在这篇综述文章中,我们强调微波加热烯烃复分解反应的应用是生物活性化合物全合成中的关键步骤。通过从最近的文献中挑选出的例子,我们的目标是说明复合反应的巨大合成能力和多种反应,以及微波辐射对常规加热源的有益作用。微波辅助烯烃复分解反应的大部分应用通过闭环复分解(RCM)和交叉复合(CM)途径覆盖了中环循环,大环化和肽模拟物的合成。
关键词: 交叉复分解,微波,天然产物,烯烃复分解,闭环复分解,钌催化剂。
Current Medicinal Chemistry
Title:Microwave-assisted Olefin Metathesis as Pivotal Step in the Synthesis of Bioactive Compounds
Volume: 24 Issue: 41
关键词: 交叉复分解,微波,天然产物,烯烃复分解,闭环复分解,钌催化剂。
摘要: Over the last two decades, olefin metathesis has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients. In many cases, syntheses based on olefin metathesis strategies provide significant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. On the other hand, over the last decade, microwave-assisted chemistry has experienced an incredible development, which rapidly opened new areas in organic synthesis and in homogeneous catalysis. In this review article, we highlight applications of microwaveheated olefin metathesis reactions as pivotal steps in the total synthesis of biologically active compounds. By drawing selected examples from the recent literature, we aim to illustrate the great synthetic power and variety of metathesis reactions, as well as the beneficial effects of microwave irradiation over conventional heating sources. The majority of the selected applications of microwave-assisted olefin metathesis cover the synthesis of medium-ring cycles, macrocycles, and peptidomimetics by means of ring-closing metathesis (RCM) and crossmetathesis (CM) routes.
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Cite this article as:
Microwave-assisted Olefin Metathesis as Pivotal Step in the Synthesis of Bioactive Compounds, Current Medicinal Chemistry 2017; 24 (41) . https://dx.doi.org/10.2174/0929867324666170314122820
DOI https://dx.doi.org/10.2174/0929867324666170314122820 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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