Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV)

Title:Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV)

Volume: 13 Issue: 5

Author(s): Yi-ning Wen, Zhi-feng Zhang, Ning-Ning Liu, Graciela Andrei, Robert Snoeck, Yu-Hong Xiang, Dominique Schols, Xue Chen, Zhuo-Yong Zhang, Qing-Shan Zhang and Qin-Pei Wu*

Affiliation:

• Department of Applied Chemistry and Pharmaceutics, Beijing Institute of Technology, Beijing 100081,China

Keywords: Antivirus, cycloaddition, herpes virus, human embryonic lung (HEL), proton derivative, thioether, triazole.

Abstract: Background: All of the clinical drugs for herpesvirus infections exhibit high toxicity and suffer from significant drug-resistantance. There is a great need for the development of new, effective, and safe anti-herpesvirus agents with different mechanisms of action.

Methods: A series of novel 5-(benzylthio)-1H-1,2,3-triazole-4-carboxamides were efficiently synthesized and EC50 values against human cytomegalovirus (HCMV), varicella-zoster virus (VZV) and herpes simplex virus (HSV) were evaluated in vitro.

Results: Some compounds possess antiviral activity. Compound 7f exhibits promising inhibitory activity against both HCMV and VZV. Our results also indicate that these derivatives are independent of the viral thymidine kinase (TK) for activation, which is indispensable for current drugs.

Conclusion: 4,5-Bissubstiuted triazoles are active against herpesviruses and the nature and the position of substituents in the benzene ring remarkably affect their activity, such as bromo, cyano and cyanovynil substituents. Future studies should be undertaken to investigate the mechanism of action of these compounds.

Cite this article as:

Wen Yi-ning, Zhang Zhi-feng, Liu Ning-Ning, Andrei Graciela, Snoeck Robert, Xiang Yu-Hong, Schols Dominique, Chen Xue, Zhang Zhuo-Yong, Zhang Qing-Shan and Wu Qin-Pei*, Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV), Medicinal Chemistry 2017; 13 (5) . https://dx.doi.org/10.2174/1573406413666170307165236

DOI https://dx.doi.org/10.2174/1573406413666170307165236	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638