Phenothiazine: A Better Scaffold against Tuberculosis

Title:Phenothiazine: A Better Scaffold against Tuberculosis

Volume: 18 Issue: 17

Author(s): Satheeshkumar Sellamuthu, Mohammad Faizan Bhat, Ashok Kumar and Sushil Kumar Singh*

Affiliation:

• Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005,India

Keywords: Phenothiazine, psychotropic, repurposing, resistance, SAR, tuberculosis.

Abstract: The incidence of Tuberculosis (TB) is baffling in developing countries due to the increase in multidrug-resistant and extensively drug-resistant TB. Therefore, drugs acting through different mechanisms are in dire need to counter the resistant strains. Various chemical scaffolds are being investigated against tuberculosis, among them the molecules containing phenothiazine nucleus are found to be more effective against both susceptible and resistant strains of M. tuberculosis. In addition, the efficacy of first-line drugs has been found to be enhanced on supplementary treatment with phenothiazines. The present review provides an overview of the phenothiazine based molecules which were investigated during the last ten years for their anti-tubercular activity.

Cite this article as:

Sellamuthu Satheeshkumar, Bhat Faizan Mohammad, Kumar Ashok and Singh Kumar Sushil*, Phenothiazine: A Better Scaffold against Tuberculosis, Mini-Reviews in Medicinal Chemistry 2018; 18 (17) . https://dx.doi.org/10.2174/1389557517666170220152651