When Good Goes Awry: The Aggregation of Protein Therapeutics

Title:When Good Goes Awry: The Aggregation of Protein Therapeutics

Volume: 24 Issue: 4

Author(s): Jennifer M. Redington, Leonid Breydo and Vladimir N. Uversky

Affiliation:

Keywords: Aggregation, formulation, storage, delivery, insulin, glucagon, antibodies

Abstract: Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a loss of efficacy and, potentially, cytotoxicity and an immunogenic response. This review describes various ways protein therapeutics aggregate and a variety of approaches taken to prevent or minimize this process.

Cite this article as:

Redington M. Jennifer , Breydo Leonid and Uversky N. Vladimir , When Good Goes Awry: The Aggregation of Protein Therapeutics, Protein & Peptide Letters 2017; 24 (4) . https://dx.doi.org/10.2174/0929866524666170209153421