Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 Diabetes

Title:Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 Diabetes

Volume: 15 Issue: 3

Author(s): Nancy Cortez-Espinosa, Laura Perez-Campos Mayoral*, Eduardo Perez-Campos, Hector Alejandro Cabrera Fuentes, Eduardo Perez-Campos Mayoral, Ruth Martínez-Cruz, Socorro Pina Canseco, Gabriel Mayoral Andrade, Margarito Martinez Cruz, Itandehui Gallegos Velasco and Pedro Hernandez Cruz

Affiliation:

• Department of Investigation Medicine-UNAM-UABJO, Faculty of School of Medicine, UABJO University, CP 60120, Oaxaca,Mexico

Keywords: Platelets, microvesicles, immune, effectors, diabetes, inflammation.

Abstract: The association between type 2 diabetes mellitus (T2DM) and systemic inflammation may increase platelet reactivity and the accelerated development of vascular disease. Platelets are able to modulate the function of immune cells via the direct release of growth factors and pro-inflammatory chemokines through the production of microvesicles. The microvesicles trigger a transcellular delivery system of bioactive molecules to other cells acting as vectors in the exchange of biological information. Here, we consider the influence of platelets and platelet-derived microvesicles on cells of the immune system and the implications in the pathogenesis of T2DM.

Cite this article as:

Cortez-Espinosa Nancy, Mayoral Perez-Campos Laura*, Perez-Campos Eduardo, Cabrera Fuentes Alejandro Hector, Mayoral Perez-Campos Eduardo, Martínez-Cruz Ruth, Canseco Pina Socorro, Andrade Mayoral Gabriel, Cruz Martinez Margarito, Velasco Gallegos Itandehui and Cruz Hernandez Pedro, Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 Diabetes, Current Vascular Pharmacology 2017; 15 (3) . https://dx.doi.org/10.2174/1570161115666170126130309