Cationic Liposomes as In Vivo Delivery Vehicles

Title: Cationic Liposomes as In Vivo Delivery Vehicles

Volume: 10 Issue: 14

Author(s): Nancy Smyth Templeton

Affiliation:

Keywords: liposomes, non-viral delivery, gene therapy, systemic delivery, formulation optimization, lamellar structures, colloidal suspensions, serum stability

Abstract: Optimization of cationic liposomal complexes for in vivo applications is complex involving many diverse components. These components include nucleic acid purification, plasmid design, formulation of the delivery vehicle, administration route and schedule, dosing, detection of gene expression, and others. This review will primarily focus on optimization of the delivery vehicle formulation. These formulation issues include morphology of the complexes, lipids used, flexibility versus rigidity, colloidal suspension, overall charge, serum stability, half-life in circulation, biodistribution, delivery to and dissemination throughout target tissues. Optimizing all components of the delivery system will allow broad use of liposomal complexes to treat or cure human diseases or disorders.

Cite this article as:

Templeton Smyth Nancy, Cationic Liposomes as In Vivo Delivery Vehicles, Current Medicinal Chemistry 2003; 10 (14) . https://dx.doi.org/10.2174/0929867033457421