药物递送纳米粒治疗化疗耐药肿瘤细胞

Title:Drug Delivery Nanoparticles in Treating Chemoresistant Tumor Cells

Volume: 24 Issue: 42

关键词: 癌症，化疗耐药机制，药物递送，miRNA / siRNA递送，纳米颗粒，米托蒽醌，柔红霉素。

摘要: Intrinsic or acquired chemoresistance represents the main obstacle to the successful treatment of cancer patients. Several mechanisms are involved in multidrug resistance: decreased uptake of hydrophilic drugs, increase of energy dependent efflux, alteration of the redox state, alteration of apoptotic pathways, and modification of the tumor microenvironment. In recent years, several types of nanoparticles have been developed to overcome these obstacles and improve the accumulation and release of drugs at the pathological site. In this review, we describe the main mechanisms involved in multidrug resistance and the nanovehicles which have been proposed to target specific aspects of this phenomenon.

Cite this article as:

Drug Delivery Nanoparticles in Treating Chemoresistant Tumor Cells, Current Medicinal Chemistry 2017; 24 (42) . https://dx.doi.org/10.2174/0929867323666161205122225