摘要
纳米技术关于血管医学方面的探索在诊断和治疗血管炎症与心血管疾病引领了新的进程。创新的纳米粒在动脉粥样硬化和动脉血管炎症靶向中扮演了重要的角色(如:炎症分子,免疫细胞和归巢细胞),已经被发展诊断和减少过度的血管炎症期待已久,有前途的临床前期和早期临床结果提高第一纳米载体在此领域的批准。这篇综述讨论了现今在生产多功能纳米粒的挑战和接下来的步骤,希望其能在未来动脉粥样硬化医学领域书写美好的未来。
关键词: 动脉粥样硬化,诊断,炎症,纳米粒,纳米疗法,血管壁。
Current Medicinal Chemistry
Title:Emerging Nanocarriers-based Approaches to Diagnose and Red uce Vascular Inflammation in Atherosclerosis
Volume: 24 Issue: 6
关键词: 动脉粥样硬化,诊断,炎症,纳米粒,纳米疗法,血管壁。
摘要: Exploitation of nanotechnology advances in the cardiovascular medicine has led to new approaches for the diagnosis and therapy of vascular inflammation associated to cardiovascular diseases. Innovative nanoparticles targeted to the main players in the arterial wall inflammation in atherosclerosis (i.e. inflammatory molecules, immune or resident cells) have been already developed to diagnose and/or reduce excessive vascular inflammation and is eagerly awaited that promising preclinical and early clinical results to boost the approval of the first nanocarrier in this field. This review discusses the challenges and the steps undertaken so far to produce powerful multifunctional nanoparticles capable of raising new scenarios for future precision medicine in atherosclerosis.
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Cite this article as:
Emerging Nanocarriers-based Approaches to Diagnose and Red uce Vascular Inflammation in Atherosclerosis, Current Medicinal Chemistry 2017; 24 (6) . https://dx.doi.org/10.2174/0929867324666161123091627
DOI https://dx.doi.org/10.2174/0929867324666161123091627 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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