Mechanisms of Phospholipase C-Regulated Calcium Entry

Title: Mechanisms of Phospholipase C-Regulated Calcium Entry

Volume: 4 Issue: 3

Author(s): Gary S. Bird, Omar Aziz, Jean-Philippe Lievremont, Barbara J. Wedel, Mohamed Trebak, Guillermo Vazquez and James W. Putney Jr.

Affiliation:

Keywords: phospholipase c, phospholipase c-linked receptors, intracellular

Abstract: In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, storeoperated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.

Cite this article as:

Bird S. Gary, Aziz Omar, Lievremont Jean-Philippe, Wedel J. Barbara, Trebak Mohamed, Vazquez Guillermo and Putney Jr. W. James, Mechanisms of Phospholipase C-Regulated Calcium Entry, Current Molecular Medicine 2004; 4 (3) . https://dx.doi.org/10.2174/1566524043360681