女人的心脏：洞察新的潜在目标治疗

Title:The Woman’s Heart: Insights into New Potential Targeted Therapy

Volume: 24 Issue: 24

关键词: 性别，雌激素，PDE5is，NO，cGMP，心脏，心血管疾病，内皮功能。

摘要: Cardiovascular disease is an increasingly common cause of death in women. There is as yet no consensus on the analysis of cardiovascular risk factors with regard to the specific, personalised treatment of pre- and post-menopausal women. Clinically significant cardioprotective and antiremodelling effects have been observed in animal and human studies exploring chronic inhibition of phosphodiesterase type 5 (PDE5).

The relationship between the heart, estrogens and PDE5 inhibitors (PDE5is) remains unclear. Experimental data suggest potential beneficial effects on cardiac geometry, function, endothelial function and microvascular coronary flow in women. It was recently postulated that the efficacy of PDE5is is estrogen-dependent in female heart disease. A registered randomised, placebo-controlled study, RECOGITO (NCT01803828), aimed at identifying the genderspecific efficacy of long-term PDE5 inhibition in diabetic cardiomyopathy, is currently recruiting patients. Estrogen receptor modulation could be a new promising approach to heart protection via PDE5is. PDE5is could be indicated as a gender-oriented strategy in modulated cardiac dysfunction and remodelling and in cardiac risk factors for selected cardiovascular diseases.

Cite this article as:

The Woman’s Heart: Insights into New Potential Targeted Therapy, Current Medicinal Chemistry 2017; 24 (24) . https://dx.doi.org/10.2174/0929867324666161118121647

DOI https://dx.doi.org/10.2174/0929867324666161118121647	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X