Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs

Title:Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs

Volume: 23 Issue: 8

Author(s): Feng Chen, Jun Jiang*, Dan-Dan Tian, Qi Wen, Yong-Hui Li, Jun-Qing Zhang, Chen Cheng and Tengfei Wang*

Affiliation:

• Hainan Medical College, 3 Xueyuan Road, Haikou 571199,China

• Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163,United States

Keywords: Obesity, cardiovascular disease, gut microbiota, oral availability conundrum, gut microbiota-herb interactions, microbiota availability.

Abstract: Cardiovascular disease still remains the primary cause of death worldwide and obesity is becoming recognized as one of the most critical contributing risk factors. The increased prevalence of obesity casts a cloud over the global health and the whole societies and will still be burdened in the future. Therefore, prevention and therapy of obesity is a beneficial strategy for the prevention of chronic cardiovascular disease. Numerous studies have demonstrated that gut microbiota takes part in human health and disease including obesity. Traditional herbs hold great potential to improve people’s health and wellness, particularly in the area of chronic inflammatory diseases although the mechanisms of action remain poorly understood. Emerging explorations of gut microbiotaherb interactions provide a potential to revolutionize the way we view herbal therapeutics. This review summarizes the experimental studies performed on animals and humans regarding the gut microbiota-herb interactions targeting obesity. This review also discusses the opportunity of herbs with potent activities but low oral bioavailability conundrum for prevention and therapy for obesity and related cardiovascular disease.

Cite this article as:

Chen Feng, Jiang Jun*, Tian Dan-Dan, Wen Qi, Li Yong-Hui, Zhang Jun-Qing, Cheng Chen and Wang Tengfei*, Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs, Current Pharmaceutical Design 2017; 23 (8) . https://dx.doi.org/10.2174/1381612822666161014115724