Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents

Title:Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents

Volume: 17 Issue: 8

Author(s): V. Kishore, Nagendra Sastry Yarla, Anupam Bishayee, Swathi Putta, Ramarao Malla, Nageswara Rao Reddy Neelapu, Surekha Challa, Subhasish Das, Yallappa Shiralgi, Gurumurthy Hegde and Bhadrapura Lakkappa Dhananjaya

Affiliation:

Keywords: Andrographis paniculata, Terpenoid, Andrographolide, Pharmacological activities.

Abstract: Andrographis paniculata (A. paniculata) is a medicinal plant used in the Indian and Chinese traditional medicinal systems for its various beneficial properties of therapeutics. This is due to the presence of a diterpene lactone called ‘andrographolide’. Several biological activities like antiinflammatory, antitumour, anti-hyperglycaemic, anti-fertility, antiviral, cardio protective and hepatoprotective properties are attributed to andrographolide and its natural analogs. The studies have shown that not only this diterpene lactone (andrographolide), but also other related terpenoid analogs from A. paniculata could be exploited for disease prevention due to their structural similarity with diverse pharmacological activities. Several scientific groups are trying to unveil the underlying mechanisms involved in these biological actions brough aout by andrographolide and its analogs. This review aims at giving an overview on the therapeutical and/or pharmacological activities of andrographolide and its derivatives and also exemplify the underlying mechanisms involved.

Cite this article as:

Kishore V., Yarla Sastry Nagendra, Bishayee Anupam, Putta Swathi, Malla Ramarao, Neelapu Rao Reddy Nageswara, Challa Surekha, Das Subhasish, Shiralgi Yallappa, Hegde Gurumurthy and Dhananjaya Lakkappa Bhadrapura, Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents, Current Topics in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1568026616666160927150452