Abstract
Forkhead box (FOX) proteins are modulator proteins that belong to a large transcription factor family, characterized by specific functions such as DNA binding, trans-activation or trans-repression. FOX DNA-binding domains, composed of evolutionarily well-conserved 100 amino acids essential for DNA recognition, a prerequisite for transcription initiation. In eukaryotic cells, FOX proteins play essential roles in a wide range of cellular and developmental processes. Recent experiments indicate that several FOX genes are mutated in ocular diseases. Ocular tissues including the lashes, eyelids, cornea, iris and lens, are affected as a result of mutations in FOXC1, FOXC2, FOXE3, FOXL2 and FOXN4. Moreover, alterations in Foxg1 and Foxd1, new emerging FOX genes, can compromise a proper projection of visual information to the brain. In addition to their role in different organ development, FOX proteins are also involved in cell cycle regulation and in signal transduction by interacting with key molecules in different pathways. This review will focus on the FOX genes directly related to the developmental genetic disorders of the eye.
Keywords: forkhead genes, ocular developmental diseases, forkhead box, ocular diseases
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
Related Books
.jpeg)
1st Biotechnology World Congress - 2012
Decolorization by Thanatephorus Cucumeris Dec 1
Industrial Applications of Soil Microbes
The Future of Agriculture: IoT, AI and Blockchain Technology for Sustainable Farming
Handbook of Integrated Weed Management for Major Field Crops
Practical Biochemistry
Anticancer Drugs Sourced from Marine Life
Opportunities for Biotechnology Research and Entrepreneurship
Diseases of Ornamental, Aromatic and Medicinal Plants
Diabetes and Breast Cancer: An Analysis of Signaling Pathways
