An Overall Picture of Chemokine Receptors: Basic Research and Drug Development

Title: An Overall Picture of Chemokine Receptors: Basic Research and Drug Development

Volume: 10 Issue: 9

Author(s): Li Chen, Gang Pei and Wenbo Zhang

Affiliation:

Keywords: chemokine receptor, g protein coupled receptor, signal transduction, ligand

Abstract: Chemokine receptors belong to the transmembrane G protein coupled receptor (GPCR) family. Although a major physiological role of chemokine receptors is for host defense by recruitment of lymphocytes to inflammatory sites, they are now found to be involved in more processes such as virus infection, tumor genesis and metastasis, and embryologic development. In this review, we show an overall picture of chemokine receptors in structure, signal transduction and modulation, physiological and pathological roles, and applying chemokine receptors for drug discovery.

Cite this article as:

Chen Li, Pei Gang and Zhang Wenbo, An Overall Picture of Chemokine Receptors: Basic Research and Drug Development, Current Pharmaceutical Design 2004; 10 (9) . https://dx.doi.org/10.2174/1381612043452749