通过给药系统治疗老年痴呆症和帕金森病的治疗方法

Title:Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems

Volume: 23 Issue: 31

Author(s): S. Cunha, M. H. Amaral, J. M. Sousa Lobo, A. C. Silva

Affiliation:

关键词: 阿尔茨海默病、帕金森病、脂质体、胶束、纳米粒子，外泌体，树枝状大分子，富勒烯

摘要: Alzheimer’s and Parkinson’s diseases are prevalent neurodegenerative disorders worldwide, which are essentially related to aging. Within the remarkable era of nanomedicine, nowadays several delivery systems have been suggested to improve the treatment of these disorders, namely, liposomes, micelles, nanoparticles (polymeric, lipid, metallic and inorganic), exosomes, dendrimers and fullerenes. The advantage that has been claimed to these delivery systems is that they facilitate the passage of drugs through the blood brain barrier (BBB), enabling targeting before body degradation, and increasing therapeutic efficacy, comparied to conventional pharmaceutical dosage forms.

This review article provides a state of the art regarding the drug delivery systems that have been studied for the treatment of Alzheimer’s and Parkinson’s diseases. It begins with a brief description of the central nervous system (CNS) and the mechanisms involved in the development of these diseases. Later, some examples of drugs used in the treatment of these neurodegenerative diseases are presented, which are currently available in conventional pharmaceutical dosage forms, and in new drug delivery systems that are under development.

Cite this article as:

S. Cunha, M. H. Amaral, J. M. Sousa Lobo, A. C. Silva , Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems, Current Medicinal Chemistry 2016; 23 (31) . https://dx.doi.org/10.2174/0929867323666160824162401