阿尔茨海默病模型中的γ-氨基丁酸微电路

Title:GABAergic Microcircuits in Alzheimer's Disease Models

Volume: 14 Issue: 1

Author(s): Vincent Villette and Patrick Dutar

Affiliation:

关键词: β-淀粉样蛋白，GABA能中间神经元，远程投射神经元，神经回路，突触传递

摘要: Background: The early phase of Alzheimer's disease (AD) involves the disruption of finely tuned neuronal circuitry in brain regions associated with learning and memory. This tuning is obtained from the delicate balance of excitatory and inhibitory inputs which regulate cortical network function. This homeostatic plasticity provides a dynamic basis for appropriate information transfer in the brain. Excitatory synaptic transmission is driven mainly by glutamatergic synapses whereas inhibitory synaptic transmission involves GABAergic and glycinergic signaling.

GABAergic cells, responsible for inhibitory transmission in adult brain, have recently become the subject of study in AD research. The discovery that GABAergic interneurons are targets of the amyloid-beta (Aβ) peptide suggest that deregulation of the excitatory/inhibitory balance contributes to changes in cortical regulation, possibly with consequences for the development of the pathology. Thus, understanding the molecular details involved in GABAergic alterations may provide insight into the pathogenesis of AD.

Objective: Here, we review recent discoveries illustrating the concept of early alterations to the inhibitory circuits in AD and consider their functional implications for GABAergic components at membrane, cellular and microcircuit levels.

Conclusion: We look at approaches that may lead to new hypotheses, animal models and therapeutic strategies based on GABAergic cells in AD with particular interest in microcircuits.

Cite this article as:

Vincent Villette and Patrick Dutar , GABAergic Microcircuits in Alzheimer's Disease Models, Current Alzheimer Research 2017; 14 (1) . https://dx.doi.org/10.2174/1567205013666160819125757

DOI https://dx.doi.org/10.2174/1567205013666160819125757	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828