Remote Neural Stimulation Using Magnetic Nanoparticles

doi:10.2174/0929867323666160814000442

摘要

神经刺激为科学家调查大脑功能和神经疾病提供了重要意义。在使用远程刺激神经回路的脑机界面也有广泛的研究兴趣。在这篇综述中，我们强调了使用磁性纳米粒产热或者运行机制推动远程大脑回路控制同时比较传统的（电刺激和药物）和第二代的（超声和光）的科技的最近进展。我们也提出了在遗传学、纳米粒合成和释放能源设备指导使用创新纳米粒平台的运用和临床设置反面的挑战和进步

关键词: mechanotranduction，趋磁细菌，铁蛋白，TRPV1，血脑屏障，thermogenetics，magnetogenetics，机械敏感性离子通道。

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Current Medicinal Chemistry

Title:Remote Neural Stimulation Using Magnetic Nanoparticles

Volume: 24 Issue: 5

关键词: mechanotranduction，趋磁细菌，铁蛋白，TRPV1，血脑屏障，thermogenetics，magnetogenetics，机械敏感性离子通道。

摘要: Neural stimulation provides a means for scientists to investigate brain functions and neurological diseases. There is also mounting interest in using remote stimulation of neuronal circuits for brain-machine interfaces. In this review, we highlight recently developed technologies utilizing magnetic nanoparticles to generate heat or exert mechanical forces for remote control of brain circuits and compare these with conventional (electrical stimulation and drugs) and second-generation (ultrasound and light) techniques. We also present some of the challenges and progress in areas like genetics, nanoparticle synthesis and energy delivery devices to translate the use of these innovative nanoparticle-based platforms in research and clinical settings.

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Remote Neural Stimulation Using Magnetic Nanoparticles, Current Medicinal Chemistry 2017; 24 (5) . https://dx.doi.org/10.2174/0929867323666160814000442

DOI https://dx.doi.org/10.2174/0929867323666160814000442	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X