摘要
通过不同的色谱技术,即气相色谱,高效液相色谱,超临界流体色谱或毛细管电色谱,经常使用低聚糖基手性固定相进行对映选择性分离。 它们的多峰应用潜力(它们与极性和/或非极性流动相兼容)使其成为用于分离各种结构不同化合物的合适的手性选择剂候选物。 在本文中,总结了在药理活性化合物分析中使用环糊精或环戊砜基手性固定相的分离系统。 该审查涉及2000年至2015年期间。该评论文章可以帮助分析人员寻找适当的分离/确定其感兴趣的药物的方法。
关键词: 环糊精,环呋喃,药物,药品,对映体分离,对映选择性,色谱。
图形摘要
Current Medicinal Chemistry
Title:Cyclic Oligosaccharide-Based Chiral Stationary Phases Applicable to Drug Purity Control; A Review
Volume: 24 Issue: 8
关键词: 环糊精,环呋喃,药物,药品,对映体分离,对映选择性,色谱。
摘要: Oligosaccharide-based chiral stationary phases are frequently used for enantioselective separations by different chromatographic techniques, namely gas chromatography, high performance liquid chromatography, supercritical fluid chromatography or capillary electrochromatography. Their multimodal application potential (they are compatible with both polar and/or non-polar mobile phases) makes them suitable chiral selector candidates for separation of a wide variety of structurally diverse compounds. In this paper, separation systems utilizing cyclodextrin- or cyclofructan-based chiral stationary phases in analyses of pharmacologically active compounds are summarized. The review covers the period from 2000 to 2015. This review article can be helpful to analysts searching for an appropriate method for the separation/determination of pharmaceuticals of their interest.
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Cite this article as:
Cyclic Oligosaccharide-Based Chiral Stationary Phases Applicable to Drug Purity Control; A Review, Current Medicinal Chemistry 2017; 24 (8) . https://dx.doi.org/10.2174/0929867323666160813221615
DOI https://dx.doi.org/10.2174/0929867323666160813221615 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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